Novel aspect for pulmonary hypertension
Novel aspect for pulmonary hypertension
Pulmonary hypertension (PH), defined as a mean pulmonary arterial pressure greater than 25 mm Hg at rest or greater than 30 mm Hg during exercise, is often characterized by a progressive and sustained increase in pulmonary vascular resistance that eventually may lead to right ventricular (RV) failure. It can be a life-threatening condition if untreated. Treatment success rates vary according to the specific cause.Cardiac disorders, pulmonary diseases, or both in combination are the most common causes of secondary pulmonary arterial hypertension (SPAH) (see the images below). Cardiac diseases produce PH via volume or pressure overload, though subsequent intimal proliferation of pulmonary resistance vessels adds an obstructive element. Perivascular parenchymal changes, along with pulmonary vasoconstriction, are the mechanisms of PH in respiratory diseases.