1. What can be done to slow the progression of renal insufficiency in ADPKD(autosomal dominant polycystic kidney disease)? Well-controlled BP and rapid treatment of UTIs may decrease the progression of renal failure.
2. Should asymptomatic older siblings of an infant with ARPKD(autosomal recessive polycystic kidney disease) be evaluated? Yes. An older child may have congenital hepatic fibrosis with minimal renal involvement.
3. Should one screen ADPKD-affected family members for the presence of cerebral vessel aneurysms if other family members have berry aneurysms? Although routine screening is not recommended, intrafamilial clustering of aneurysms has been reported and it may be advisable to screen children with MRI or cranial CT in a family with aneurysms.
(Modified from 5-Minute Pediatric Consult book)